Hydrogel Micro And Nanoparticles

Hydrogel Micro and Nanoparticles PDF
Author: L. Andrew Lyon
Publisher: John Wiley & Sons
ISBN: 3527646442
Category : Technology & Engineering
Languages : un
Pages : 430

Get Book

Hydrogel Micro And Nanoparticles

by L. Andrew Lyon, Hydrogel Micro And Nanoparticles Books available in PDF, EPUB, Mobi Format. Download Hydrogel Micro And Nanoparticles books, The book provides experienced as well as young researchers with a topical view of the vibrant field of soft nanotechnology. In addition to elucidating the underlying concepts and principles that drive continued innovation, major parts of each chapter are devoted to detailed discussions of potential and already realized applications of micro- and nanogel- based materials. Examples of the diverse areas impacted by these materials are biocompatible coatings for implants, films for controlled drug release, self-healing soft materials and responsive hydrogels that react to varying pH conditions, temperature or light.



The Design Of Multifunctional Hydrogel Nanoparticles For Drug Delivery

The Design of Multifunctional Hydrogel Nanoparticles for Drug Delivery PDF
Author: Michael Hughes Smith
Publisher:
ISBN:
Category : Colloids
Languages : un
Pages :

Get Book

The Design Of Multifunctional Hydrogel Nanoparticles For Drug Delivery

by Michael Hughes Smith, The Design Of Multifunctional Hydrogel Nanoparticles For Drug Delivery Books available in PDF, EPUB, Mobi Format. Download The Design Of Multifunctional Hydrogel Nanoparticles For Drug Delivery books, Hydrogel micro- and nanoparticles (microgels and nanogels) are a promising class of drug delivery vehicles. Composed of hydrophilic polymers arranged into a cross-linked network structure, nanogels show several attractive features for the delivery of macromolecule therapeutics. For instance, the hydrated, porous internal cavity of the nanogel may serve as a high capacity compartment for loading macromolecules, whereas the periphery of the nanogel may be used as a scaffold for conjugating cell-specific targeting moieties. This dissertation presents recent investigations of nanogels as targeted delivery vehicles for oligonucleotides to cancer cells, while exploring new nanogel chemistries that enable future in vivo applications. For instance, synthetic efforts have produced particles capable of erosion into low molar mass constituents, providing a possible mechanism of particle clearance after repeated administration in vivo. In another example, the microgel network chemistry was tuned to promote the encapsulation of charged proteins. In parallel with those synthetic efforts, new light scattering methodologies were developed to accurately quantify the particle behaviors (e.g. loading, erosion). Using multiangle light scattering (MALS), changes in particle molar mass and radius were measured, providing a quantitative and direct approach for monitoring nanogel erosion and macromolecule encapsulation. The new particle chemistries demonstrated, together with enabling light scattering methods, will catalyze the development of improved delivery vehicles in the near future.



Perspectives In Micro And Nanotechnology For Biomedical Applications

Perspectives in Micro  and Nanotechnology for Biomedical Applications PDF
Author: Juliana M Chan
Publisher: World Scientific
ISBN: 1783269626
Category : Science
Languages : un
Pages : 312

Get Book

Perspectives In Micro And Nanotechnology For Biomedical Applications

by Juliana M Chan, Perspectives In Micro And Nanotechnology For Biomedical Applications Books available in PDF, EPUB, Mobi Format. Download Perspectives In Micro And Nanotechnology For Biomedical Applications books, Perspectives in Micro- and Nanotechnology for Biomedical Applications is an exciting new book that takes readers inside the fast-paced world of biomedical sciences fueled by advancements in nanotechnology, polymer chemistry and pharmacology. Guided by biotech researchers Chenjie Xu and Juliana Chan, an international ensemble of leading experts in the field cover topics ranging from classical chemical tools to nanoparticles as imaging probes and drug carriers, and combinatorial screens for new lipids and polymers. At the microscale it discusses advancements in hydrogels and platform technologies such as cell ghosts. This book provides a broad perspective into the basic principles and applications of today's most promising micro- and nanotechnologies, and is an up-to-date reference book for researchers. It is also suitable for undergraduate and graduate students, patent lawyers and investors who are interested in the latest innovations taking place in the biomedical sciences, many of which may dramatically improve the lives of millions of people.



Nanomaterials For Drug Delivery And Therapy

Nanomaterials for Drug Delivery and Therapy PDF
Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128166290
Category : Medical
Languages : en
Pages : 580

Get Book

Nanomaterials For Drug Delivery And Therapy

by Alexandru Mihai Grumezescu, Nanomaterials For Drug Delivery And Therapy Books available in PDF, EPUB, Mobi Format. Download Nanomaterials For Drug Delivery And Therapy books, Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers



Development And Evaluation Of Enzymatically Degradable Hydrogel Microparticles For Pulmonary Delivery Of Nanoparticles And Biologics

Development and Evaluation of Enzymatically degradable Hydrogel Microparticles for Pulmonary Delivery of Nanoparticles and Biologics PDF
Author: Prinda Wanakule
Publisher:
ISBN:
Category :
Languages : un
Pages : 498

Get Book

Development And Evaluation Of Enzymatically Degradable Hydrogel Microparticles For Pulmonary Delivery Of Nanoparticles And Biologics

by Prinda Wanakule, Development And Evaluation Of Enzymatically Degradable Hydrogel Microparticles For Pulmonary Delivery Of Nanoparticles And Biologics Books available in PDF, EPUB, Mobi Format. Download Development And Evaluation Of Enzymatically Degradable Hydrogel Microparticles For Pulmonary Delivery Of Nanoparticles And Biologics books, The emerging class of biologic drugs, including proteins, peptides, and gene therapies, are widely administered by injection, despite potential systemic side effects. Rational design of targeted carriers that can be delivered non-invasively, with reduced side effects, is essential for the success of these therapies, as well as for the improvement of patient compliance and quality of life. One potential approach is to take advantage of specific physiological cues, such as enzymes, which would trigger drug release from a drug carrier. Enzymatic cleavage is highly specific and could be tailored for certain diseased tissues where specific enzymes are up regulated. Enzymatically-degradable hydrogels, which incorporate an enzyme- cleavable peptide into the network structure, have been extensively reported for releasing drugs for tissue engineering applications. These studies showed that a rapid response and corresponding drug release occurs upon enzyme exposure, whereas minimal degradation occurs without enzyme. Recently, Michael addition reactions have been developed for the synthesis of such enzymatically-degradable hydrogels. Michael addition reactions occur under mild physiological conditions, making them ideally suited for polymerizing hydrogels with encapsulated biologic drugs without affecting its bioactivity, as in traditional polymerization and particle synthesis. The focus of my research was to create enzymatically-degradable hydrogel microparticles, using Michael addition chemistry, to evaluate for use as an inhalable, disease-responsive delivery system for biologic drugs and nanoparticles. In this dissertation, I utilize bioconjugation and Michael addition chemistries in the design and development of enzymatically-degradable hydrogels, which may be tailored to a multitude of disease applications. I then introduce a new method of hydrogel microparticle, or microgel, synthesis known as the Michael Addition During Emulsion (MADE) method. These microgel carriers were evaluated in vitro, and found to exhibit triggered release of encapsulated biologic drugs in response to enzyme, no significant cytotoxic effects, and the ability the avoid rapid clearance by macrophages. Lastly, in vivo studies in mice were conducted, and microgels were found to exhibit successful delivery to the deep lung, as well as prolonged pulmonary retention after intratracheal aerosol delivery. In conclusion, a new class of enzymatically-degradable microgels were successfully developed and characterized as a versatile and promising new system for pulmonary, disease-responsive delivery of biologic drugs.



Nanostructured Polymer Blends

Nanostructured Polymer Blends PDF
Author: Sérgio Roberto Montoro
Publisher: Elsevier Inc. Chapters
ISBN: 0128090871
Category : Technology & Engineering
Languages : un
Pages : 576

Get Book

Nanostructured Polymer Blends

by Sérgio Roberto Montoro, Nanostructured Polymer Blends Books available in PDF, EPUB, Mobi Format. Download Nanostructured Polymer Blends books, Polymer systems can be developed into a variety of functional forms to meet industrial and scientific applications. In general, they are presented in four common physical forms: (1) linear free chains in solution, (2) covalently or physically cross-linked reversible gels, (3) micro and nanoparticles, and (4) chains adsorbed or in surface-grafted form. Hydrogels are polymeric particles consisting of water-soluble polymer chains, chemically or physically connected using, in general, a cross-linking agent. These materials do not dissolve in water but may swell considerably in aqueous medium, demonstrating an extraordinary ability (>20%) to absorb water into the reticulated structure. Such features make these materials promising tools in the biomedical field, especially as controlled drug release systems. This chapter describes recent progress in the development and applications of polymeric nanostructured hydrogels, mainly in the context of biomedical devices. Additionally, it reports the significant advances in synthesis and characterization strategies of these materials. Special attention is devoted to smart or stimuli-responsive bionanogels, which mimic the property of living systems responding to environmental changes such as pH, temperature, light, pressure, electric field, chemicals, or ionic strength, or a combination of different stimuli. Consequently, these bionanogels offer an efficient solution to various biomedical limitations in the field of drug administration.



Emerging Nanotechnologies In Dentistry

Emerging Nanotechnologies in Dentistry PDF
Author: Karthikeyan Subramani
Publisher: William Andrew
ISBN: 1455778621
Category : Medical
Languages : un
Pages : 410

Get Book

Emerging Nanotechnologies In Dentistry

by Karthikeyan Subramani, Emerging Nanotechnologies In Dentistry Books available in PDF, EPUB, Mobi Format. Download Emerging Nanotechnologies In Dentistry books, Nanotechnology and the future of Dentistry -- Nanoparticles for Dental Materials: Synthesis, analysis and Applications -- Antimicrobial nanoparticles in Restorative Composites -- Nanotechnology in operative dentistry: a perspective approach of history, mechanical behavior and clinical application -- Nanotechnology and dental implants -- Titanium surface modification techniques for dental implants - From microscale to nanoscale -- Titanium nanotubes as carriers of osteogenic growth factors and antibacterial drugs for applications in dental implantology -- Cellular responses to nanoscale surface modifications of titanium implants for dentistry and bone tissue engineering applications -- Corrosion Resistance of Ti6Al4V with Nanostructured TiO2 Coatings -- Multiwalled Carbon Nanotubes/Hydroxyapatite Nanoparticles incorporated GTR membranes -- Fabrication of PEG hydrogel micropatterns by Soft-photolithography and PEG hydrogel as Guided Bone Regeneration membrane in dental implantology -- Na ...



Particulate Flows And Heteroaggregation Studied By Optical Imaging And Fluorescence Spectroscopy

Particulate Flows and Heteroaggregation Studied by Optical Imaging and Fluorescence Spectroscopy PDF
Author: Kapil V. Deshpande
Publisher:
ISBN:
Category : Fluorescence spectroscopy
Languages : un
Pages : 142

Get Book

Particulate Flows And Heteroaggregation Studied By Optical Imaging And Fluorescence Spectroscopy

by Kapil V. Deshpande, Particulate Flows And Heteroaggregation Studied By Optical Imaging And Fluorescence Spectroscopy Books available in PDF, EPUB, Mobi Format. Download Particulate Flows And Heteroaggregation Studied By Optical Imaging And Fluorescence Spectroscopy books, The production of multiscale heteroaggregates of microparticles coated with nanoparticles has generated renewed interest in recent literature due to the wide-ranging applications of such structured particles. These applications include particle stabilization, nanotemplating, and drug delivery, among others. In the past, the majority of heteroaggregation studies and associated applications have involved rigid, spherical particles. However, as part of a multiscale heteroaggregate, hydrophilic hydrogel particles can be used to open a whole range of new applications. These hydrogel particles have also been of great interest recently due to their significant microencapsulation capabilities and variety of delivery mechanisms. This dissertation is focused on gaining understanding of the heteroaggregation of hydrogel microparticles and nanoparticles and of particulate flows that could potentially be used to influence aggregate formation. First, concentrated noncolloidal particle suspensions undergoing oscillatory torsional flow between parallel plates were studied using optical imaging. Much of the work focuses on the effect of moderate strain amplitude and frequency on particle migration. Also explored were various effects that can lead to enhanced or reduced particle migration in the flow. Next, a new quantitative application of fluorescence spectroscopy was developed in order to study the interaction of oppositely charged hydrogel microparticles and nanoparticles in suspensions. Optical microscopy was first used to determine the type of aggregate morphology formed by mixtures of alginate microparticles and fluorescently tagged chitosan nanoparticles at different concentration levels. It was hypothesized that due to fluorophore and particle interaction properties that fluorescence spectroscopy would be able to quantify the boundaries between different types of interactions in the system. With this new technique, the effect of the concentration ratio of nanoparticles to microparticles and the total overall particle concentration was also explored. Finally, after developing the application of fluorescence spectroscopy for quantifying particle interaction, varying the pH of the interaction environment where heteroaggregation occurs was studied. pH is an important parameter in hydrogel microcapsule and nanocapsule delivery and in heteroaggregation behavior. The change in interaction behavior of alginate and chitosan particles was explored and the capabilities and limits of fluorescence spectroscopy were determined.



Aquananotechnology

Aquananotechnology PDF
Author: Kamel A. Abd-Elsalam
Publisher: Elsevier
ISBN: 0128211423
Category : Technology & Engineering
Languages : un
Pages : 626

Get Book

Aquananotechnology

by Kamel A. Abd-Elsalam, Aquananotechnology Books available in PDF, EPUB, Mobi Format. Download Aquananotechnology books, Aquananotechnology: Applications of Nanomaterials for Water Purification focuses on the impacts of, and opportunities for, the application of nanotechnology to enhance water quality and the societal concerns surrounding the widespread use of nanotechnology in the water arena. Sections cover the use of nano-sensors for the detection of water pollutants, the control of waterborne pathogens, and the use of nano-biochar coal fly composites for phytoremdtions wastewater pollutants. In addition, the book explores the uses of nanoadsorbents for heavy metals, dyes, Arsenic, pesticides, and water/wastewater remediation and decontamination of water from xenobiotics, bionanocomposites, metal oxides, silver, zinc nanoparticles, and carbon-based nanomaterials for wastewater treatment. In addition, the book covers the use of zerovalent iron nanomaterials and nanostructured mesoporous silica for water purification, along with nano-hydrogels to increase water efficiency and conservation. Finally, the socioeconomic impacts and risks of aquananotechnology in ecosystems are discussed. This book provides a detailed description of the ecological applications of nanomaterials in aquatic environments, offering a cogent analysis of both major applications and challenges. Shows how a range of nanomaterial types are being used for ecological applications in aquatic environments Explores the effects different types of nanomaterials have on a variety of ecosystems Assesses the major challenges of using nanotechnology to improve water quality on a mass scale